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Open access Aug 2026

Oligodendrocyte dysfunction in human age-related cognitive decline.

Cognitive decline in aging impacts quality of life, for which therapeutic interventions are lacking. Why some individuals experience more severe cognitive decline with aging is unclear. Here we uncover a role for the brain's myelin-forming cells-oligodendrocytes-in explaining this variance. By investigating neuropathol...

Georgina A. Craig, Emeric Merour, L. Seeker et al. · 0 citations
Open access Oct 2026

Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All‐Cause Mortality

ABSTRACT Ageing biomarkers quantify molecular, physiological or functional features that vary between individuals as they age and may improve prediction of health outcomes beyond chronological age. Recently, plasma proteomics have been used to estimate the biological ages of 11 human organs. Although accelerated organ...

M. Pyrgioti, I. Eguiagaray, P. Redmond et al. · 0 citations

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