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Open access Oct 2026

Association between polygenic liability to depression and lifetime depression in at-risk adolescents.

Internalising symptoms including depression, anxiety and somatic symptoms in adolescence are common. They can be transient, but they can also persist and progress to major depressive disorder (MDD) Polygenic risk scores for major depression (MD-PGS) may help identify which symptomatic adolescents are at greatest risk o...

E. Byrne, Nathan A. Gillespie, J. Najman et al. · 0 citations
Open access Sep 2026

Longer Sleep Duration Predicts Progression to Bipolar or Psychotic Disorders in Youth Accessing Early Intervention Mental Health Services

ABSTRACT Background While growing evidence implicates sleep‐wake and circadian rhythm disturbances (SCRDs) in the onset and course of mood and psychotic disorders, longitudinal studies using objective measures are limited. This clinical cohort study examined whether actigraphy‐derived SCRDs (sleep duration, timing, and...

J. Carpenter, J. Crouse, M. Varidel et al. · 0 citations

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