BACKGROUND
Invasive fungal infections are associated with high morbidity and mortality, particularly among immunocompromised and critically ill patients. Antifungal therapy is complicated by substantial pharmacokinetic variability, drug-drug interactions, and narrow therapeutic windows for some agents. Although therape...
J. Cusato, A. Cafaro, S. Cairoli et al.· Therapeutic Drug Monitoring· 0 citations
OBJECTIVE
This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings.
MATERIALS AND METHODS
A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for...
Giorgia Pieretto, J. Cusato, Martina Sansavini et al.· Oral Diseases· 0 citations
Assessment of several computational approaches using a dataset of pharmacogenomic variants with either clinical annotations or functional characterization by deep mutational scanning, with an additional focus on CYP2C9, a clinically relevant drug-metabolizing enzyme, indicates that computational models can complement i...
F. Pucci, Pauline Hermans, Matsvei Tsishyn et al.· bioRxiv· 0 citations
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