Author

J. de Vos-Geelen

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Review Open access Sep 2026

Real-world implementation of a decision aid for treatment decisions in metastatic pancreatic cancer: a prospective multicenter study across expert centers

Abstract Background Treatment decisions in metastatic pancreatic adenocarcinoma (mPAC) involve complex tradeoffs between survival benefits and treatment burden. Shared decision-making (SDM) is crucial but challenging in emotionally charged and time-pressured consultations. This study evaluated the real-world implementa...

M. Graus, Thijmen H. T. Broekman, S. V. van Nassau et al. · The Oncologist · 0 citations

Open access Sep 2026

Thrombin dynamics and clinical events in cirrhosis: low prothrombin conversion predicts bleeding risk

Pro- and anti-coagulant factors are significantly altered in liver cirrhosis resulting in an increased bleeding and thrombosis risk. The thrombin generation (TG) test often seems unaltered in cirrhosis, indicating that a new hemostatic balance is reached. TG is determined by prothrombin conversion and thrombin inactiva...

R. Willems, A. Zanetto, E. Campello et al. · Frontiers in Cell and Develo... · 0 citations

Open access Jul 2026

Sedentary behavior and physical activity are longitudinally associated with diurnal cortisol rhythms in individuals up to 1 year after colorectal cancer treatment: A prospective cohort study

Higher physical activity levels, a larger RA of physical activity, and less sedentary time were associated with more robust diurnal cortisol rhythms, suggesting these behaviors may be targets for interventions aimed at improving cortisol rhythmicity after CRC.

Koen G. Frenken, F. Scheer, J. Qian et al. · Research Square · 0 citations