Author

J. De Waele

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Open access Oct 2026

A false sense of circularity: hidden variability in RNase R enzymes confounds reliable circRNA validation

Circular RNAs (circRNAs) are an emerging class of RNA molecules involved in development and disease. They are generated through back-splicing from pre-mRNA. RNaseR treatment, which degrades linear RNA while preserving circRNAs, is widely used for circRNA validation and enrichment. This short report demonstrated differe...

Lotte Ulrix, J. De Waele, J. Vandesompele et al. · bioRxiv · 0 citations

Open access Oct 2026

A homozygous GABRA2 variant associated with infantile spasms evolving to Lennox-Gastaut syndrome alters receptor gating.

Variants in GABAA receptor subunits are increasingly implicated in developmental and epileptic encephalopathies. Although GABRA2 variants have been associated with early-onset epilepsy, the functional consequences of individual variants, particularly those located outside canonical ligand-binding and transmembrane pore...

J. De Waele, Marcelo Diaz-Bustamante, Najat Aourz et al. · Neurobiology of Disease · 0 citations