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Open access Sep 2026

260. Prescription medication use, healthcare utilisation and genetic risk for addiction: a phenome-wide association and Mendelian randomization study

Abstract Background Substance Use Disorders (SUDs) are major contributors to global morbidity and premature mortality. While their adverse physical and psychiatric sequalae are widely attributed to toxic effects of substance exposure, accumulating evidence suggests that inherited liability to addiction also shapes broa...

M. Graczyk, C. Albiñana, A. Lee et al. · 0 citations
Open access Sep 2026

728. Environmental, psychiatric, and genetic predictors of alcohol use disorder criterion count

Abstract Background Genetic and environmental factors, and psychiatric traits, contribute to risk for alcohol use disorder (AUD) and other substance use disorders (SUDs) and traits. Weighing the importance of the different kinds of contribution to risk is important in understanding risk prediction – which may be import...

P. Na, J. Deak, D. Levey et al. · 0 citations
Open access Aug 2026

Genomic Architecture of Migraine: A Multi ancestry GWAS Meta analysis of 2.5 Million Participants

Migraine is a leading cause of disability, yet preventive treatment remains largely empirical despite the availability of several mechanistically distinct therapies. Genetic data can clarify mechanisms and therapeutic hypotheses when association signals are integrated with molecular and clinical data. We meta-analyzed...

C. Overstreet, M. Galimberti, K. Harsan et al. · 0 citations

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