Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis, divides lung NETs into grade-1 typical, and grade-...
A. Sexton-Oates, É. Mathian, N. Candeli et al.· Molecular Cancer· 1 citation
It is demonstrated that downregulation of PLCG2, primarily in neurons, impairs synaptic function and elevates amyloid-β levels and Tau protein phosphorylation in neurons.
Audrey Coulon, F. Rabiller, M. Takalo et al.· Nature Genetics· 0 citations
It is concluded that rare coding CNVs in a proportion of AD-associated genes and 22q11.21 duplication as a strong AD-risk-decreasing factor increase AD risk and Conversely, 22q11.21 duplication as a strong AD-risk-decreasing factor is identified.
O. Quenez, Catherine Schramm, K. Cassinari et al.· American Journal of Human Ge...· 1 citation
This study identifies EXTL3 as a genetic modifier of structural severity in AS and reveals a previously unrecognised role for HS metabolism in pathological ossification, which supports a model in which HLA-B27 primarily confers disease susceptibility, whereas rare variants such as EXTL3 contribute to structural progres...
S. Hilliquin, Olivier Fogel, Mathilde Tissier et al.· Annals of the Rheumatic Dise...· 0 citations
A high-resolution placental mQTL resource is constructed and systematically investigated how placental DNAm relates to early- and later-life traits, and to shared vulnerability and complex interactions among them.
A. Cilleros-Portet, Itziar González-Moro, Hachem Sadikki et al.· medRxiv· 0 citations
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