Open access
Aug 2026
A single-amino-acid cleavage controls global mitochondrial complex integrity.
Mitochondrial proteostasis depends on precise N-terminal processing of imported precursor proteins. Defects in this maturation step are implicated in disease, yet the functional impact in humans remains unclear. Here we show that the intermediate cleaving peptidase ICP55, which removes a single amino acid, acts as a ke...
Cansu Küçükköse, Marcin Luzarowski, F. Stockert et al.
· Nature Structural & Molecula... · 1 citation