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Open access Oct 2026

Outcomes following biliary decompression interventions for jaundiced patients with malignant intrahepatic obstruction from metastatic cancer.

293 Background: Hyperbilirubinemia due to malignant intrahepatic biliary obstruction frequently limits eligibility for systemic therapy. Intrahepatic biliary drainage interventions (IBDI), including endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic biliary drainage (PTBD), are...

Tessa Crilley, Adeel Arshad, Mitchell L. Ramsey et al. · 0 citations
Review Open access Sep 2026

CD38 in hepatic pathobiology: mechanisms, disease association and therapeutic implications.

CD38 is a highly conserved multifunctional enzyme that regulates intracellular calcium signaling and NAD⁺ metabolism. Although extensively studied in cancer and autoimmune diseases, growing evidence points to a critical role for CD38 in both normal and diseased liver physiology. In hepatic tissue, CD38 is expressed on...

J. Eng, Blake R. Peterson, Sylvester M. Black · 0 citations

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