Author

J. Fernández-Costa

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Review Open access Oct 2026

Modeling cancer cachexia: from preclinical platforms to biosensing innovations.

Cancer cachexia is a multifactorial and progressive syndrome characterized by the not fully reversible loss of skeletal muscle and adipose tissue, which significantly impairs treatment tolerance, quality of life, and patient survival. Despite its high clinical burden, cachexia remains underdiagnosed and undertreated, l...

Rita Lima-Sousa, Aike Sijtsma, Lucília Pereira da Silva et al. · Seminars in Cancer Biology · 0 citations

Open access Jul 2026

A bioengineered platform reveals progressive impairment of skeletal muscles by metabolic dysfunction-associated steatotic liver disease-derived factors

A modular human three-dimensional bioengineered liver–muscle platform is developed to dissect causal liver–muscle crosstalk and provides a testbed for perturbations and interventions targeting liver-driven muscle wasting.

A. Cortés-Reséndiz, J. Fernández-Costa, M. Sabater-Arcís et al. · Disease Models & Mechanisms · 1 citation