Author

J. Flaws

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Review Aug 2026

Mechanisms by which "Everywhere" and "Forever" Environmental Chemicals Impact Ovarian Function and Female Fertility.

Phthalates and per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants that are consistently detected in follicular fluid, serum, and reproductive tissues. This review synthesizes current experimental and epidemiological evidence on the molecular and cellular mechanisms by which phthalates...

Daniel Um, J. Flaws · Biology of Reproduction · 0 citations

Sep 2026

The aryl hydrocarbon signaling pathway in the ovary changes throughout reproductive aging and in response to a mixture of phthalates over time in mice.

Phthalates are plasticizers and solvents used in numerous consumer products. Exposure to a phthalate mixture (Mix) alters estrous cyclicity, fertility indices, ovarian follicle dynamics, and steroidogenesis. In cultured antral follicles, phthalates alter the aryl hydrocarbon receptor (AHR) pathway, which is known for e...

A. E. Dean, R. Santacruz-Márquez, A. Safar et al. · Toxicological Sciences · 0 citations

Sep 2026

Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate alters the aryl hydrocarbon receptor signaling pathway in the ovary throughout reproductive aging in mice.

Overall, DEHP and DiNP both influence the ovarian AHR pathway, but at different time points and doses.

A. E. Dean, R. Santacruz-Márquez, A. Safar et al. · Toxicological Sciences · 0 citations

Open access Aug 2026

Chronic Di(2-ethylhexyl) phthalate and Diisononyl phthalate Exposure Impairs Uterine Endometrial Glycogen Metabolism in Mice.

Results show that phthalates alter endometrial glycogen levels and expression of key enzymes, which are consistent with altered glycogen metabolism, which could alter endometrial glucose metabolism.

P. Zarei, Isabella Raneri, Garima Thapa et al. · Reproductive Toxicology · 0 citations

Open access Jul 2026

Acute Exposure to Di(2-ethylhexyl) Phthalate or Diisononyl Phthalate Leads to Increased Inflammation and Oxidative Stress in the Uteri of Mice.

It is demonstrated that acute exposure to DEHP and DiNP induces uterine inflammatory and oxidative stress responses, with distinct dose-dependent effects for each phthalate.

Adriana Andrus, L. Y. Parra-Forero, Coba N Sexton et al. · Reproductive Toxicology · 1 citation