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Preprint Aug 2026

GenFAR: A generalized representation of brain structure, derived from 49,246 multi-cohort MRIs via deep learning

GenFAR, a modular deep learning framework that learns general, clinically informed features from brain MRIs, is introduced, showing that using the learned feature representation can substantially increase the sample efficiency of secondary deep learning training tasks and models, as well as improve their accuracy.

V. Bashyam, G. Erus, Jun-Hao Wen et al. · 0 citations
Open access Sep 2026

Shared genetic architecture between brain iron deposition and Alzheimer's disease

Brain iron accumulation is well established in Alzheimer's disease (AD), but whether the two share a genetic basis remains unclear. Here, we performed genome-wide association analyses of brain iron across six iron-rich brain regions, quantified via quantitative susceptibility mapping (QSM) in 38,142 UK Biobank particip...

M. R. Rahman, Y. Xia, P. Raniga et al. · 0 citations

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