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J. G. Stolwijk

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Open access Sep 2026

Siglec-1-targeting single domain antibodies block or enhance pathogen binding to dendritic cells.

Siglec-1 (Sialoadhesin/CD169), expressed on myeloid cells, is a receptor for sialic acids that mediates adhesion to host cells and pathogens. However, certain pathogens exploit Siglec-1 binding for further dissemination and interfering with this binding may serve as potential therapeutic interventions. Here we identifi...

H. J. Brink, A. Affandi, S. Man et al. · 0 citations
Open access Jul 2026

Siglec-1-targeted nanobodies restrict HIV-1 transmission and infection of dendritic cells

Newly developed single-domain antibodies against Siglec-1 are used against Siglec-1 as a candidate inhibitor to limit HIV-1 transmission and support the development of host-directed nanobody-based strategies to reduce HIV-1 spread.

S. Man, A. Affandi, H. Brink et al. · 0 citations

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