Summary Paragraph Personality traits describe stable differences in how people think, feel, and behave and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustness, generalizability,...
T. Schwaba, Margaret L. Clapp Sullivan, W. Akingbuwa et al.· Nature· 5 citations· ⚡1
Abstract Background Substance Use Disorders (SUDs) are major contributors to global morbidity and premature mortality. While their adverse physical and psychiatric sequalae are widely attributed to toxic effects of substance exposure, accumulating evidence suggests that inherited liability to addiction also shapes broa...
M. Graczyk, C. Albiñana, A. Lee et al.· International Journal of Neu...· 0 citations
BACKGROUND
Bipolar disorder (BD) studies consistently implicate the ventral prefrontal cortex (VPFC) in association with suicidal behaviors. A suicidal behavior polygenic risk score (PRS) can now be computed to test whether elevated genetic risk for suicidal behavior is associated with variation in VPFC gray matter and...
Noa Katz Shroitman, D. Levey, Brian P. Pittman et al.· Bipolar Disorders· 0 citations
Regression analyses showed that PTSD case status was significantly associated with accelerated DNA methylation aging, and smoking status stratification suggested that the association between PTSD and methylation of the AHRR gene may be confounded by smoking status.
Sarah Beck, D. Levey, M. Galimberti et al.· medRxiv· 0 citations
In this sample, ADHD was associated with increased risk for SUDs and earlier onset of substance use and genetic liability to ADHD was independently associated with multiple SUDs and SUD criteria counts.
Michael R. Setzer, R. Kember, Emily E. Hartwell et al.· Psychological Medicine· 0 citations
Abstract Background Genetic and environmental factors, and psychiatric traits, contribute to risk for alcohol use disorder (AUD) and other substance use disorders (SUDs) and traits. Weighing the importance of the different kinds of contribution to risk is important in understanding risk prediction – which may be import...
P. Na, J. Deak, D. Levey et al.· International Journal of Neu...· 0 citations
These findings expand the known genetic architecture of migraine across ancestries and provide a genetics-led map connecting association signals with biological pathways, multimorbidity and candidate therapeutic mechanisms, providing a foundation for future functional and translational studies.
C. Overstreet, M. Galimberti, K. Harsan et al.· medRxiv· 0 citations
OBJECTIVE
Suicidal ideation (SI) and suicide attempt (SA) are both influenced by genetic, behavioral, and environmental factors. Alcohol use disorder (AUD) and adverse childhood experiences (ACEs) may mediate or moderate the effects of genetic liability for suicidality.
METHODS
Using data from 10,275 participants (43...
V. Wu, X. Qin, A. Ashley-Koch et al.· Journal of Affective Disorde...· 0 citations
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