Open access
Jul 2026
Spatial multi-omics identifies early synaptic pruning and context-specific dopaminergic vulnerability in synucleinopathies
It is shown that early complement associated pruning of inhibitory synapses precedes overt α-synuclein aggregation and neuronal loss in prodromal synucleinopathy, indicating disease-context dependent relationships between αSyn pathology and neurodegeneration.
Svenja-Lotta Rumpf, Felix L. Struebing, Karsten Nalbach et al.
· Nature Communications · 0 citations