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Author

J. Gokey

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Open access Sep 2026

IPF distal lung epithelial cells acquire a DNA methylation signature consistent with activation of basal cell transcriptional programs

High-resolution DNA methylation profiling of purified distal lung epithelial cells from 10 age-matched control and 14 IPF lungs identified widespread methylome remodeling in the IPF lung epithelium, potentially providing future therapeutic strategies by identifying putative regulatory elements associated with aberrant...

A. Colvard, Stefano A. Iantorno, I. P. Gaona et al. · 0 citations
Open access Jul 2026

Emergence of Disease-relevant Aberrant Epithelial Cell States in Human Alveolar Organoids.

How primary human alveolar epithelial organoids respond to a commonly-used commercial alveolar differentiation media intended to facilitate AT2->AT1 differentiation (ADM) in isolation and following biased HIF activation is investigated to position HIF2 as a critical potentiator of aberrant alveolar epithelial cell stat...

H. David, A. Dietrich, C. Calvi et al. · 1 citation

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