J. Graff-Radford

Instrumented Walkway Gait Analysis Predicts Fallers in Neurological Disorders: Identifying Digital Biomarkers for Balance Monitoring

Assessing balance is crucial in neurological rehabilitation, yet while wearable sensors enable real-world monitoring, identifying reliable digital biomarkers remains challenging. This study utilized a high-fidelity instrumented walkway to determine which gait parameters best predict balance impairment, providing robust...

Clinical pathways for cognitively unimpaired individuals with Alzheimer's disease neuropathological change.

The recent approval of disease-modifying therapies for symptomatic Alzheimer's disease is a major advance for a condition with few therapeutic options. Anti-amyloid monoclonal antibodies have shown clinically meaningful benefits in slowing cognitive decline. Clinical trials in symptomatic Alzheimer's disease suggest th...

Diagnostic accuracy of remote self-administered digital cognitive assessment by clinical diagnosis and Alzheimer’s disease PET imaging biomarkers

INTRODUCTIONCognitive characterization is increasingly important for Alzheimers disease treatment decisions, highlighting the need for scalable cognitive assessment. We evaluated the diagnostic accuracy of a remote self-administered cognitive screening battery, Mayo Test Drive (MTD), across clinically and biologically...

Neuroimaging in the era of biologically defined Alzheimer's disease and disease-modifying therapy.

Neuroimaging is now a cornerstone of Alzheimer's disease care and a crucial discriminator tool for characterising brain injury across the lifespan and with emerging fluid biomarkers, neuroimaging supports accurate diagnosis, prognosis, and treatment monitoring.

Fluid biomarkers in the evolving care landscape of Alzheimer's disease and related disorders.

Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression.

Findings lend support for PVS-BG as an early indicator of small vessel dysfunction and WMH pathogenesis and suggest that PVS-BG may identify individuals at increased risk of progressive SVD.

Diffusion MRI identifies a prolonged Pre-WMH Phase in Cerebral Small Vessel Disease

Diffusion MRI biomarkers were abnormal at least a decade before WMH abnormality in the population, revealing a prolonged phase of early SVD and highlighting their potential for SVD prevention.

Targeted proteomics of postmortem human brain reveals neurobiologic heterogeneity in Alzheimer’s disease using NULISA technology

Proteomic differences in synapse integrity, tau post-translational modification, and ubiquitination associated with age at symptomatic onset and corticolimbic distribution of tangle pathology are observed.