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J. Hakizimana

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Review Open access Sep 2026

Bidirectional Neuro‐Immune Interactions of the Orexin/Hypocretin System: A Systematic Review With Conceptual Synthesis

Beyond regulating sleep, the orexin/hypocretin system participates in bidirectional neuro‐immune interactions that may influence neurodegenerative diseases (NDs) and chronic inflammatory conditions. This systematic review aimed to conceptually synthesize evidence on these interactions and their clinical implicati...

J. Hakizimana, Zephyrin Izukwizabigenza, M. Kampire et al. · 1 citation

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