Open access
Jul 2026
Reassessing Tcf21-iCre for Adult Cardiac Fibroblast Gene Deletion: Limited Recombination Efficiency Following Tamoxifen Injections
Highlights What are the main findings? Tcf21-iCre demonstrates minimal recombination efficiency in adult cardiac fibroblasts after tamoxifen injection, with mono-allelic events indicating low Cre activity. Neither pro-fibrotic stress nor additional tamoxifen dosing improves recombination efficiency. What are the implic...
A. Schober, Lukas Müller, R. Wardman et al.
· Cells · 0 citations