Integrated analysis of hematopoietic changes following heterochronic bone marrow transplantation between young and aged mice.
BACKGROUND aging is a multifactorial process characterized by progressive loss of tissue homeostasis and regenerative capacity, with haematopoiesis being profoundly affected. Age-associated changes in hematopoietic stem cells (HSCs) include increased frequency but reduced function, impaired self-renewal, and myeloid bi...