BACKGROUND
Kidney failure affects approximately 800,000 adults in the United States, and African Americans carry a disproportionate burden of disease. Robust algorithms for clinical risk prediction, such as the Kidney Failure Risk Equation (KFRE), have previously been validated, whereas the clinical utility of polygeni...
Alana C. Jones, Atlas Khan, Amit Patki et al.· American Society of Nephrolo...· 0 citations
Age is a major risk factor for many diseases, but the biological processes driving aging are heterogeneous across individuals. Efforts to untangle differences between chronological and biological age have focused on identifying age-associated markers, such as ’omics clocks. Many ’omics features, including proteins, are...
M. Gillman, H. Chen, A. Howard et al.· bioRxiv· 0 citations
Beyond arterial lipid deposition, TRL and Lp(a) converge on inflammatory and vascular remodeling pathways that, under the assumptions of observational mediation analysis, may explain their excess per-particle atherogenicity compared with LDL.
J. Morze, E. Björnson, Michael Y. Mi et al.· European Heart Journal· 0 citations
This work fine-mapped UK Biobank-derived genome-wide association study (GWAS) signals from 164 traits and identified e/sQTL colocalizations for 10,611 GWAS signals, including 7096 that colocalize with secondary e/sQTLs.
Peter Orchard, T. Blackwell, L. Kachuri et al.· Science· 0 citations
Which sleep PRS performed well across diverse populations and which sleep definitions better captured genetic underpinnings was highlighted by evaluating several types of sleep PRSs and sleep phenotypes.
A. Wyss, Michael Brown, Xiang Li et al.· Sleep· 0 citations
This study supports methylation risk scores as novel biomarkers of stress-related CHD and uncovers epigenetic regulation in monocytes as a potential underlying mechanism of stress-related CHD, highlighting biological pathways linking stress and disease and may promote personalized interventions in high-risk populations...
Sofia Benavides, Hazel Milla, Helena Palma-Gudiel et al.· medRxiv· 0 citations
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