Author

J. J. Enghild

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Open access Oct 2026

Interspecies regulation of virulence through gingipain inhibition by a Tannerella forsythia serpin.

Periodontitis is driven by dysbiotic microbial communities in which Porphyromonas gingivalis (Pg) acts as a keystone pathogen through its caspase-like fold (Clan CD) proteases, gingipains. Tannerella forsythia (Tf), another member of the periodontal pathogenic community, uniquely produces the broad-spectrum serpin term...

M. Ksiazek, M. Benedyk-Machaczka, D. Mizgalska et al. · EMBO Reports · 0 citations

Oct 2026

The IKK complex and TBK1/IKKε are recruited to STING through distinct mechanisms to activate NF-κB signaling.

Stimulator of interferon genes (STING) is a highly conserved signaling molecule that coordinates an antiviral innate immune response through activation of the nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) signaling pathways. In addition to an antiviral response, STING-mediated NF-κB signaling also...

A. Christensen, Aneta Jurkiewicz, Cathrine Silberbauer Jensen et al. · Science immunology · 0 citations