Open access
Jul 2026
Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning
It is shown that D2Rs can bypass second messenger systems to tune glutamatergic transmission through receptor-receptor interactions, providing a mechanism by which dopamine selectively gates specific glutamatergic inputs to control striatal plasticity and behavioral adaptation.
Sheng Gong, J. Adler, Ying Zhu et al.
· Science Advances · 0 citations