Open access
Sep 2026
Multivalent Anti-ACE2 Nanobodies Confer Broad Pan-Sarbecovirus Protection
A nanobody discovery pipeline incorporating competition-based yeast surface display assays is optimized to isolate single-chain variable heavy chain-only antibody domains (VHHs or nanobodies) that bind human ACE2 and inhibit SARS-CoV-2 entry, showcasing their potential as broadly acting receptor-targeted biologics agai...
A. Bakasis, Rachel Patejak, Peter C. Fridy et al.
· bioRxiv · 0 citations