ECC-MR: an error-correcting-code framework for robust Mendelian randomization and pleiotropy decoding on correlated instruments
Mendelian randomization (MR) uses genetic variants as instrumental variables for causal inference, but its validity is often undermined by horizontal pleiotropy and linkage disequilibrium (LD) among instruments, which current methods typically address by discarding correlated or outlying variants. Here we present ECC-M...