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Author

J. Joubert

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Open access Sep 2026

Criteria-guided selection of alternative zinc-binding groups of HDAC3 inhibitors using in silico and in vitro approaches.

Histone deacetylases (HDACs) are epigenetic enzymes linked to several biological functions and diseases. Class I HDACs (HDAC1-3) share high protein sequence and active site similarity. Hydroxamate-based inhibitors, while highly potent, are non-selective with poor pharmacokinetic profile, prompting exploration of altern...

Thabo Brighton Makgoba, Samuel Egieyeh, E. Kapp et al. · 0 citations

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