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Author

J. Kennelly

2 papers indexed here

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Open access Oct 2026

NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

Findings position NK2R as a molecular switch for intestinal lipid handling and mucosal inflammation and suggest that NK2R-targeted agonists or antagonists could be deployed as context- and sex-dependent therapeutic strategies for metabolic disease and inflammatory bowel disease.

P. A. Perez, Chung-Chih Liu, Alessandra Ferrari et al. · 0 citations
Open access Sep 2026

Design and structural basis of selective nonsteroidal inhibitors of aster cholesterol trafficking

Significance Cholesterol transport by Aster proteins from the plasma membrane (PM) to the endoplasmic reticulum is important for cholesterol homeostasis. We identify nonsteroidal Aster inhibitors with improved specificity and reduced toxicity compared to sterol-based inhibitors. YKJ-124, a low-toxicity Aster-A preferri...

Hyunsoo Kim, B. Romartínez-Alonso, Xu Xiao et al. · 0 citations

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