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Author

J. Klein

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Open access Oct 2026

Selective vulnerability of human basal forebrain subsystems in ageing and neuropsychiatric disorders

INTRODUCTION: The basal forebrain (BF) provides the principal cholinergic innervation to the cortex and the hippocampus and is among the earliest regions affected by neurodegenerative processes. Yet, whether its subnuclei differ in how their structural integrity changes with age and in their vulnerability to neurologic...

T. Eisenstein, M.-T.-M. Hu, J. Klein · 0 citations
Open access Aug 2026

Sex-dependent dopaminergic vulnerability may contribute to sex differences in Parkinson’s disease risk

By distinguishing baseline variation from age-related changes in a selectively vulnerable dopaminergic system, this study provides population-scale evidence relevant to understanding sex differences in vulnerability to Parkinson’s disease.

T. Eisenstein, F. Lange, Michele T. M. Hu et al. · 0 citations

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