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Open access Aug 2026

A Phosphorylation-Independent Monoclonal Antibody Improves Detection of TDP-43 Pathology Across FTLD, ALS, and LATE-NC

TDP-43 proteinopathies encompass frontotemporal lobar degeneration with TDP-43 pathology (FTLD TDP), amyotrophic lateral sclerosis (ALS TDP), and limbic predominant age related TDP-43 encephalopathy neuropathological change (LATE NC), all of which exhibit subtype-specific aggregate architectures that may constrain epit...

Xiao-Jing Zheng, Ning Zhang, Li-Xia Wang et al. · 0 citations
Open access Aug 2026

Association of age with clinical progression across plasma p-tau217 levels

BACKGROUND: Chronological age and plasma p-tau217 each predicts cognitive decline, but whether their prognostic associations interact is unclear. In this study, we examined their joint associations in a memory-clinic cohort. METHODS: We included 3,741 participants from the Pittsburgh ADRC, with up to 28 years of follow...

R. Shi, L. Choity, S. Brodman et al. · 0 citations
Open access Jul 2026

Multi-model Segmentation and Morphometric Quantification of Cerebral Amyloid Angiopathy in Alzheimer’s Disease Whole Slide Histopathology Images

A scalable, interpretable solution for vessel-level CAA analysis is provided, supporting robust geometric and spatial characterization of cerebrovascular pathology and enabling future integration with clinical and genetic studies.

H. Tahmasebidehkordi, A. Bahramy, Dana R. Julian et al. · 0 citations

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