TDP-43 proteinopathies encompass frontotemporal lobar degeneration with TDP-43 pathology (FTLD TDP), amyotrophic lateral sclerosis (ALS TDP), and limbic predominant age related TDP-43 encephalopathy neuropathological change (LATE NC), all of which exhibit subtype-specific aggregate architectures that may constrain epit...
Xiao-Jing Zheng, Ning Zhang, Li-Xia Wang et al.· Journal of Neuropathology an...· 0 citations
BACKGROUND: Chronological age and plasma p-tau217 each predicts cognitive decline, but whether their prognostic associations interact is unclear. In this study, we examined their joint associations in a memory-clinic cohort. METHODS: We included 3,741 participants from the Pittsburgh ADRC, with up to 28 years of follow...
R. Shi, L. Choity, S. Brodman et al.· medRxiv· 0 citations
A scalable, interpretable solution for vessel-level CAA analysis is provided, supporting robust geometric and spatial characterization of cerebrovascular pathology and enabling future integration with clinical and genetic studies.
H. Tahmasebidehkordi, A. Bahramy, Dana R. Julian et al.· bioRxiv· 0 citations
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