Frontotemporal lobar degeneration (FTLD), predominantly comprised of tau and TDP-43 proteinopathies, is a common cause of early-onset dementia. Biomarkers that reliably classify FTLD subtypes are limited, thereby hindering in-vivo diagnosis and clinical trial stratification. We conducted large-scale, multi-platform cer...
R. Saloner, L. Cornelis, Joshua Downer et al.· bioRxiv· 0 citations
Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated with menopause and its links to brain aging. In n = ...
Madeline Wood Alexander, Jennifer S. Rabin, Michelle R. Caunca et al.· Nature Medicine· 1 citation
Traditional community outreach, research recruitment, and engagement strategies in aging neuroscience often fail to target and capture the diversity of structural and environmental conditions that shape the risk of age-related neurocognitive disorders (NCDs), including Alzheimer’s disease. In this manuscript, we descri...
S. Lanata, C. Windon, B. Tee et al.· Frontiers in Public Health· 0 citations
A double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use, and positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads).
G. Blazhenets, D. Soleimani-Meigooni, Konstantinos Chiotis et al.· Journal of the American Medi...· 5 citations
Preliminary evidence of the relationship between subjective sleep preferences and objective circadian data in cognitively healthy older adults with notable sex differences in these relationships is provided.
Natalie S. Pandher, L. Yack, E. Li et al.· PLoS ONE· 0 citations
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