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Open access Jul 2026

Structure-guided computational design and mechanistic understanding of the p95HER2-targeting NAZ-mAb antibody and its variants

A practical framework for computationally driven, developability-aware antibody optimization in the absence of experimental structural data is provided and shows that the computational workflow can generate experimentally tractable, antigen-engaging NAZ-mAb variants, while also highlighting the limitations of fixed-bac...

P. Rawat, J. Kyte, Victor Greiff et al. · 0 citations

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