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J. L. Lee

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Open access Oct 2026

Paired Transcriptomic Profiling Identifies Shared Liver Metastasis-Associated Molecular Features in Colorectal Cancer

Colorectal cancer liver metastasis (CCLM) is closely associated with poor patient prognosis, yet patient-specific molecular heterogeneity complicates the identification of recurrent molecular changes during metastasis. To address this, we performed RNA sequencing on paired primary tumors and liver metastases synchronou...

H. Lee, Seok-Soon Park, M. Kwon et al. · 0 citations
Open access Jul 2026

Spatial Multi-Platform Integration Reveals Distinct Tumor States and Microenvironmental Niches in Colitis-Associated Colorectal Cancer 2309487

The invasive tumor phenotype is associated with CAF and SPP1+ macrophage proximity and SPP1—CD44-mediated signaling, highlighting the tumor microenvironment as a potential therapeutic target in C-CRC.

Yoonho Lee, Yongjae Kim, J. Baek et al. · 0 citations

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