Open access
Sep 2026
Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease
A validated WMH global-PRS is generated showing robust association with cSVD clinical complications and introduce a multi-cohort WMH ps-PRS framework that reveals candidate biological pathways with candidate biological associations across the lifespan and clinical outcomes.
T. D'Aoust, A. Tsuchida, C. Dufouil et al.
· medRxiv · 0 citations