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J. Lambert

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Open access Sep 2026

Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease

A validated WMH global-PRS is generated showing robust association with cSVD clinical complications and introduce a multi-cohort WMH ps-PRS framework that reveals candidate biological pathways with candidate biological associations across the lifespan and clinical outcomes.

T. D'Aoust, A. Tsuchida, C. Dufouil et al. · 0 citations

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