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A reproducibility-based framework for developing and transferring DNAm algorithms on the MSA, where reduced probe content does not preclude reproducible DNA methylation biomarker measurement, and transfer strategy must be matched to model architecture.
BACKGROUND Breastfeeding reduces ovarian cancer risk, but the underlying biological mechanisms remain unclear. METHODS We examined the association between a previously reported metabolite-based breastfeeding score with incident epithelial ovarian cancer risk in case-control studies nested within the Nurses' Health St...
Aging biomarkers can potentially allow researchers to rapidly monitor the impact of an aging intervention without the need for decade-spanning trials. However, before the use of aging biomarkers, such as epigenetic clocks, as surrogate endpoints, their responsiveness to interventions that target aging must be tested. H...
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