Author

Jeannette Lechner-Scott

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Open access Oct 2026

X-chromosome methylation patterns in females with multiple sclerosis

Findings identify a reproducible X-chromosome hypomethylation signature in female MS and support direct investigation of inactive-X regulation, XCI escape and X-linked immune gene dosage.

T. Calnin, V. Maltby, S. Burnard et al. · medRxiv · 0 citations

Open access Sep 2026

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility

Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.

Lu Zeng, Atlas Khan, Kathryn C. Fitzgerald et al. · Nature Genetics · 0 citations