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Open access Aug 2026

The Drp1 inhibitor DRP1i2 confers cardioprotection against doxorubicin-induced cardiotoxicity

It is demonstrated that DRP1i2 confers cardioprotection while maintaining anticancer efficacy via modulation of Drp1-dependent mitochondrial dynamics, supporting mitochondrial fission as a targetable pathway to mitigate doxorubicin-induced cardiotoxicity.

Yali Deng, S. Bass-Stringer, S. Bond et al. · 0 citations
Open access Aug 2026

An Integrated Cardiac Microtissue Proteome Map Extends Therapeutic Remodeling by Nanovesicles

It is defined that administration of NVs (from human induced pluripotent stem cell origin) during reoxygenation during reoxygenation significantly increase CM survival and preserve contractility function and the findings provide an advanced human stem cell-based platform to understand underlying mechanisms of IRI and a...

Jonathan Lozano, J. Lees, Jonathon Cross et al. · 0 citations

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