The anti-apoptotic molecule BCL-2 favours the maintenance of the CD4+ T-cell reservoir during HIV infection. Whether inhibition of BCL-2 can lead to long-term reduction of the HIV reservoir is unclear. Here we initiated antiretroviral therapy (ART) in 24 simian immunodeficiency virus (SIV)-infected rhesus macaques at 1...
T. R. Wiche Salinas, J. Harper, C. Deleage et al.· Nature Microbiology· 0 citations
Early antiretroviral therapy (ART) limits viral reservoir establishment in infants but also constrains viral-specific immunity required to clear reactivated cells. In the early ART context, we evaluated whether combining adeno-associated virus serotype 9 (AAV9)-vectored eCD4-IgG1 with pharmacologic latency reversal usi...
Jairo A. Fonseca, Alexis C. King, Kaleaha S. Davis et al.· JCI Insight· 0 citations
People living with HIV (PLWH) on suppressive antiretroviral therapy (ART) can face non-AIDS complications, partially driven by chronic immune activation. To define immune perturbations during ART-suppressed viral infection, we performed longitudinal single-cell transcriptomic and plasma proteomic analyses of rhesus mac...
Maanasa Kaza, B. Varco-Merth, G. McElfresh et al.· Cell Reports· 0 citations
The majority of persons living with HIV-1 who discontinue antiretroviral therapy (ART) demonstrate viral rebound, but the tissue-level events that lead to rebound viremia remain poorly understood. Here we report the origin, dynamics, and correlates of viral rebound in 16 rhesus macaques (RMs) infected with molecularly...
Irena V. King, Malika Aid, Emek Kose et al.· Science Translational Medici...· 0 citations
It is suggested that KIR3DL01+ NK cells contribute to the inhibition of SIV replication during chronic infection, and the feasibility of AAV-vectored antibody delivery for long-term, perhaps indefinite depletion of a lymphocyte subset in a nonhuman primate model is demonstrated.
Kjell Sandstrom, Grace N. Hagedorn, Sean C Robinson et al.· PLoS Pathogens· 0 citations
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