Author

J. Lutz

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Open access Aug 2026

mRNA-based immunotherapy improves the efficacy of adoptively transferred TCR transgenic T cells in a murine solid tumour model

Results demonstrate that mRNA immunotherapy can substantially enhance the efficacy of TCRtg T cell therapy in a solid tumour model, and holds promise for overcoming key limitations of ACT by boosting T cell expansion, persistence, infiltration, and functional capacity within the tumour microenvironment.

J. Krueger, Janne J. Ruotsalainen, J. Lutz et al. · Scientific Reports · 1 citation