Latent Genetic Factors and Causal Pathways Linking Substance Use to Psychiatric and Personality Phenotypes: a Genomic SEM and Mendelian Randomization Study
Substance use and psychiatric disorders frequently co-occur, but establishing causality of their relationships is difficult given the multifactorial nature of these traits. To assess these relationships, we applied two genetically informed methods using the largest available European-ancestry genome-wide association st...