An APOE-independent polygenic risk score for Alzheimer’s disease derived from multiancestry GWAS summary statistics shows consistent associations with cognitive, imaging, biomarker and neuropathological features in diverse populations.
N. Kurniansyah, S. Tasaki, H. Rehman et al.· Nature Genetics· 0 citations
The observed genetic correlations are consistent with shared genetic liability between DED and chronic pain, autoimmune, and psychiatric traits, but do not establish causal direction.
Bryan R. Gorman, Jaxon J. Huang, Peter B. Barr et al.· EBioMedicine· 0 citations
Regression analyses showed that PTSD case status was significantly associated with accelerated DNA methylation aging, and smoking status stratification suggested that the association between PTSD and methylation of the AHRR gene may be confounded by smoking status.
Sarah Beck, D. Levey, M. Galimberti et al.· medRxiv· 0 citations
These findings expand the known genetic architecture of migraine across ancestries and provide a genetics-led map connecting association signals with biological pathways, multimorbidity and candidate therapeutic mechanisms, providing a foundation for future functional and translational studies.
C. Overstreet, M. Galimberti, K. Harsan et al.· medRxiv· 0 citations
PTSD was associated with advanced epigenetic aging in the largest study to date to evaluate this question, and effects were generally small in magnitude, though meaningful when considering the personal and healthcare system impact of advanced aging in the large population of VA users with PTSD.
E. Wolf, R. Zhang, X. Zhao et al.· medRxiv· 0 citations
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