Open access
Sep 2026
Pharmacological modulation with the LXR agonist T0901317 attenuates motor pathology in the SOD1G93A mouse model of ALS
Dysregulation of cholesterol metabolism and neuroinflammation are critical drivers of Amyotrophic Lateral Sclerosis (ALS) pathology. Liver X receptors (LXRs) are master regulators of cholesterol homeostasis and immune responses. Here, we evaluated the therapeutic potential of chronic pharmacological modulation using th...
Luis C. Fernández-Beltrán, Irene García-Toledo, Karen Javaloyes García et al.
· Neurotherapeutics · 0 citations