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J. Mahlangu

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Review Open access Sep 2026

Future management of hemophilia a with non-biologic hemostatic agents: a call for precision coagulation.

INTRODUCTION The therapeutic landscape of hemophilia A has expanded beyond factor replacement with the emergence of non-biologic pharmacological strategies that modulate endogenous hemostatic pathways. These innovations challenge traditional treatment paradigms and create opportunities for more individualized approache...

J. Mahlangu · 0 citations
Review Sep 2026

An evaluation of denecimig for bleeding prophylaxis in hemophilia A.

INTRODUCTION Despite advances in factor VIII (FVIII) replacement and emicizumab prophylaxis, people with hemophilia A may experience breakthrough bleeding, progressive joint disease, treatment burden, and inhibitor-related limitations. Denecimig (Mim8) is a fully human, next-generation FVIIIa-mimetic bispecific antibod...

J. Mahlangu · 0 citations

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