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Author

J. Manautou

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2 papers indexed here

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Review Sep 2026

From Pathogenesis to Therapy: Extracellular Vesicles Orchestrate Cellular Crosstalk in Acetaminophen Hepatotoxicity.

Drug-induced liver injury (DILI) is a major cause of acute liver failure, with acetaminophen (APAP) overdose representing the leading cause of intrinsic hepatotoxicity worldwide. Although the mechanisms of APAP-induced liver injury have been extensively characterized, recent evidence highlights a critical role for extr...

Ankit P. Laddha, C. Ghanem, J. Manautou · 0 citations
Sep 2026

MRP4 deficiency exacerbates diet-induced MASLD through dysregulation of hepatic lipid handling.

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is characterized by impaired hepatic lipid homeostasis. Multidrug resistance-associated protein 4 (MRP4/ABCC4) is a sinusoidal efflux transporter of endogenous signaling metabolites. We previously showed that Mrp4 knockout (Mrp4-/-) mice develop prolonged...

Hang-Yu Wu, Ankit P. Laddha, Neha Mishra et al. · 0 citations

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