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Author

J. Mintseris

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Open access Oct 2026

Ribosome remodeling drives translation adaptation during viral infection and cellular stress

Summary The ribosome is the highly conserved molecular machine that decodes mRNAs during protein synthesis. While traditionally thought to consist of a uniform set of proteins, here we discover that ribosome composition is reprogrammed to adapt to intrinsic and external cellular perturbations. During infection of human...

Hsin-Yu Tsai, Luo-Chen Liu, R. H. Fleming et al. · 1 citation
Jul 2026

An AI-enabled structural atlas decodes kinase specificity across the human proteome.

KinoPlex, a computational framework that integrates predicted protein structures and kinase recognition motifs to assign phosphorylation potential and kinase specificity to all serine/threonine/tyrosine residues, is presented.

David Vanderwall, Edward L. Huttlin, J. Mintseris et al. · 0 citations

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