Open access
Sep 2026
Fixed Nonsynonymous vOka Vaccine Mutations in IE62 drive Varicella-Zoster Virus Attenuation in Human Skin
The live, attenuated vaccine for Varicella-Zoster Virus (VZV) protects against chickenpox in children and adults. However, the vaccine strain Oka (vOka) establishes latency and may reactivate. The molecular basis of vOka attenuation remains unknown. We investigated whether three high-frequency single-nucleotide polymor...
Reuben O. Onwe, Joao Ferreira, M. Lloyd et al.
· bioRxiv · 0 citations