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Sep 2026

Age-Associated Cognitive Deviations in Early-Onset Psychosis Patients and Their Siblings.

OBJECTIVE The objective of this study was to test for cognitive impairments and cross-sectional age-associated cognitive deviations in a large, diagnostically diverse, cross-sectional sample of children and adolescents with early-onset psychosis (EOP), their siblings, and nonpsychotic psychiatric control participants....

J. Mollon, N. Lanzagorta, Samuel R. Mathias et al. · 0 citations
Open access Aug 2026

Determinants of functional burden pleiotropy and gene dosage responses across human traits

Pleiotropic and monotonic effects of gene dosage are central to understanding comorbidities in developmental pediatric and psychiatric disorders, yet the underlying biological processes are not well characterized. Here we develop a functional burden analysis to investigate the association of all protein-coding copy-num...

Sayeh Kazem, Kuldeep Kumar, J. Yang et al. · 0 citations

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