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J. P. Pineda-Gómez

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Open access Sep 2026

830. Galanin(1-15) and Naltrexone: A novel approach for alcohol use disorder in rats, involving the mesolimbic system

Abstract Background Alcohol Use Disorder (AUD) is one of the most prevalent psychiatric conditions and represents a major public health burden worldwide. Despite available pharmacotherapies, including naltrexone (NTX)—a mu-opioid receptor (MOR) antagonist—therapeutic efficacy remains limited due to side effects and sig...

M. Flores-Gómez, N. Cantero-García, J. P. Pineda-Gómez et al. · International Journal of Neu... · 0 citations

Open access Sep 2026

Early socially isolated rats of both sexes reduce alcohol consumption and seeking by the Galanin (1–15) and naltrexone combination

Background Alcohol Use Disorder (AUD) is a psychiatric condition whose severity can be amplified by social factors, such as social isolation, particularly during adolescence, which exacerbates development of AUD in adulthood. Our previous studies have demonstrated that the Galanin (1–15) fragment [GAL (1–15)] reduces a...

M. Flores-Gómez, N. Cantero-García, J. P. Pineda-Gómez et al. · Frontiers in Pharmacology · 0 citations

Open access Sep 2026

839. A new pharmacological strategy against treatment-resistant depression

This study demonstrates that GAL(1–15) significantly enhances FLX’s antidepressant efficacy in a treatment-resistant depression model, and supports a synergistic interaction between galanin and serotonergic systems involving GALR2 and 5-HT1A receptor modulation, particularly within the PFC.

J. P. Pineda-Gómez, C. Millón, N. Cantero-García et al. · International Journal of Neu... · 0 citations