Author

J. Palade

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Open access Sep 2026

TDP-43 dysfunction induces cryptic circular RNAs in ALS/FTD

Nuclear depletion of TDP-43 is a defining pathological feature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), leading to widespread RNA misprocessing, including the formation of cryptic exons. Here, we identified TDP-43 as a regulator of circular RNA (circRNA) biogenesis in multiple human neu...

Dario Dattilo, F. Pellegrini, Simone Barattucci et al. · bioRxiv · 0 citations

Open access Aug 2026

SALRR: Scalable Analysis of Long-Read RNA-Seq Enables Comprehensive Transcriptome Profiling in Human Brain

Isoform-resolved transcriptomics is fundamental to decoding the molecular complexity of the human brain, yet population-scale long-read RNA sequencing has remained inaccessible due to labor-intensive library preparation, sensitivity to RNA degradation in postmortem tissue, and the absence of integrated, reproducible an...

C. Kouam, Jackson Mingle, Pilar Álvarez Jerez et al. · bioRxiv · 0 citations

Open access Jul 2026

Extracellular vesicles from cytokine-treated human pancreatic ductal cells enhance HLA class I expression in beta cells

Introduction/objective Type 1 diabetes (T1D) is an autoimmune disease characterized by the loss of insulin-producing beta cells and has no cure. The role of cell-cell interactions in T1D disease progression remains poorly understood. Beta cells develop adjacent to ductal cells and both cell types undergo changes during...

Neslihan Erdem, H. Zook, Janine C. Quijano et al. · Frontiers in Immunology · 0 citations