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Open access Sep 2026

Exercise elicits mitonuclear protein imbalance and UPRmt in the liver of mice with obesity

Mitochondrial dysfunction plays a critical role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). It has been proposed that mitochondrial unfolded-protein response (UPRmt) activation improves mitochondrial function in the liver. Growing evidence demonstrates that physical exercise...

M. B. Rocha, Izabela Monteiro de Araújo, Saulo Gabriel Do Nascimento Della Coleta et al. · 0 citations
Review Open access Sep 2026

Integrated Multi-Omics Network by Physical Exercise Across Aging: Molecular Adaptation Beyond Single Signaling Pathways.

Aging is characterized by progressive molecular dysregulation across interconnected biological systems, involving alterations in epigenetic regulation, gene expression, protein homeostasis, and metabolic function. Although physical exercise is widely recognized as one of the most effective non-pharmacological intervent...

Guilherme da Silva Rodrigues, I. V. de Sousa, Takuji Kawamura et al. · 0 citations

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