Author

J. Pérez-Simón

3 papers indexed here

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Open access Sep 2026

Integrated analysis of hematopoietic changes following heterochronic bone marrow transplantation between young and aged mice.

BACKGROUND aging is a multifactorial process characterized by progressive loss of tissue homeostasis and regenerative capacity, with haematopoiesis being profoundly affected. Age-associated changes in hematopoietic stem cells (HSCs) include increased frequency but reduced function, impaired self-renewal, and myeloid bi...

J. A. Bejarano-García, Melanie Nufer, Rocío Caracuel et al. · Transplantation and Cellular... · 0 citations

Open access Aug 2026

Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients.

Pegtarazimod reduced aGVHD in mice by suppressing pro inflammatory neutrophil effector functions and preserving enterocyte integrity and the clinical trial data support tolerability of pegtarazimod in aGVHD patients and further studies are needed to determine efficacy.

Verena Holzmüller, Jana Gawron, Ann-Cathrin Burk et al. · Journal of Clinical Investig... · 0 citations

Open access Jul 2026

Bridging preclinical development and clinical manufacturing: a translational GMP-Platform for lentiviral vector production in academic CAR T-Cell therapy

An integrated GMP facility is established and validated for aseptic LV production within a public healthcare setting, establishing a GMP-compliant academic platform for scalable LV manufacturing, enabling decentralized, cost-effective, and clinically compliant supply.

Maribel Lara-Chica, Blanca Arribas-Arribas, Raquel Muñoz-García et al. · Journal of Translational Med... · 0 citations